Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6139695 | Virology | 2015 | 9 Pages |
Abstract
We characterized the full-length genomes of 22 hepatitis C virus genotype 6 (HCV-6) isolates: 10 from Vietnam (classified into subtypes 6e, 6h, 6p, 6r, 6s, and 6u), one from China (confirmed as a new subtype 6xd), and 11 from the Lao PDR (representing a new subtype 6xe plus eight novel variants). With these 22 new genomes, HCV-6 now has a diverse and extended taxonomic structure, comprised of 28 assigned subtypes (denoted 6a-6xe) and 27 unassigned lineages, all of which have been represented by full-length genomes. Our phylogenetic analyses also included many partially-sequenced novel variants of HCV-6 from Lao PDR. This revealed that Lao HCV isolates are genetically very diverse and are phylogenetically distributed in multiple lineages within genotype 6. Our results suggest that HCV-6 has been maintained in Laos, a landlocked country, since the common ancestor of genotype 6 and indicates historical dispersal of HCV-6 across Southeast Asia.
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Authors
Chunhua Li, Eleanor Barnes, Paul N. Newton, Yongshui Fu, Manivanh Vongsouvath, Paul Klenerman, Hiroaki Okamoto, Kenji Abe, Oliver G. Pybus, Ling Lu,