Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6139869 | Virology | 2014 | 11 Pages |
Abstract
Immunization of macaques with attenuated simian immunodeficiency virus (SIV) with deletions in nef (SIVÎnef) is shown to elicit protective immunity to infection by pathogenic SIV, yet the mechanisms that orchestrate protection and prevent pathogenesis remains unknown. We utilized whole-genome transcriptional profiling to reveal molecular signatures of protective immunity in circulating CD8+ T cells of rhesus macaques vaccinated with SIVmac239Înef and challenged with pathogenic SIVmac251. Our findings suggest that protective immunity to pathogenic SIV infection induced by SIVmac239ânef is associated with balanced induction of T cell activation and immunoregulatory mechanisms and dampened activation of interferon-induced signaling pathways and cytolytic enzyme production as compared with pathogenic SIVmac251 infection of unvaccinated controls. We provide evidence that protective immunity to SIVmac251 correlates with induction of biomarkers of T cell activation, differentiation, signaling, and adhesion that were down regulated in unvaccinated controls. The study highlights potential immunomodulatory networks associated with protective immunity against the virus.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Michael D. George, William Hu, James M. Billingsley, R. Keith Reeves, Sumathi Sankaran-Walters, R. Paul Johnson, Satya Dandekar,