Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6140109 | Virology | 2014 | 11 Pages |
Abstract
HIV-exposed seronegative individuals (HESNs) are persons who possess in vivo resistance against HIV. Using iTRAQ, we compared protein abundance profiles from cervicovaginal fluid (CVF) samples obtained from HESNs with samples from low-risk seronegative and from seropositive persons. Serpin A5 and myeloblastin were up- and downregulated, respectively. We hypothesize that a balance between the downregulation of serine proteinases and the upregulation of their inhibitors may contribute to HIV-resistance 156
Keywords
CVFARVMCPITRAQBCATLRMCDbicinchoninic acid assayAcetonitrilescxFormic acidinterleukinisobaric tags for relative and absolute quantificationstrong cation exchangefold changeToll-like receptorHigh-riskLow-riskAntiretroviralreversed phaseconfidence intervalMALDICervicovaginal fluidHIV resistanceCANbacterial vaginosishuman immunodeficiency virusHIVProteomicsmonocyte chemotactic protein
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Authors
Geert Van Raemdonck, Geert Zegels, Edmond Coen, Bea Vuylsteke, Wim Jennes, Xaveer Van Ostade,