Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6140423 | Virology | 2014 | 9 Pages |
Abstract
The entry of canine distemper virus (CDV) is a multistep process that involves the attachment of CDV hemagglutinin (H) to its cellular receptor, followed by fusion between virus and cell membranes. Our laboratory recently identified PVRL4 (nectin-4) to be the epithelial receptor for measles and canine distemper viruses. In this study, we demonstrate that the V domain of PVRL4 is critical for CDV entry and virus cell-to-cell spread. Furthermore, four key amino acid residues within the V domain of dog PVRL4 and two within the CDV hemagglutinin were shown to be essential for receptor-mediated virus entry.
Keywords
Related Topics
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Immunology and Microbiology
Virology
Authors
Sebastien Delpeut, Ryan S. Noyce, Christopher D. Richardson,