| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6141033 | Virology | 2013 | 10 Pages |
Abstract
⺠We studied the contribution of SAM and HD domains to the ability of SAMHD1 to block HIV-1 infection. ⺠The sole HD domain of SAMHD1 is sufficient to achieve potent restriction of HIV-1 and SIVmac. ⺠The HD domain of SAMHD1 is essential for the ability of SAMHD1 to oligomerize and bind RNA. ⺠Double stranded RNA inhibits the dNTPase activity of SAMHD1. ⺠Expression of SAMHD1 or the sole HD domain blocks infection of HIV-2, FIV, BIV, EIAV, N-MLV and B-MLV.
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Authors
Tommy E. White, Alberto Brandariz-Nuñez, Jose Carlos Valle-Casuso, Sarah Amie, Laura Nguyen, Baek Kim, Jurgen Brojatsch, Felipe Diaz-Griffero,