Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6141057 | Virology | 2013 | 10 Pages |
Abstract
⺠The SIV mRNAs encoding Rev and Env protein have an upstream AUG codon. ⺠This upstream uAUG4 down-regulates Rev protein expression. ⺠By down-regulating Rev translation, uAUG4 up-regulates Env translation. ⺠uAUG4 “Kozak strength” and overlap with the Rev ORF ensure optimal Env translation. ⺠uORF4 is an important regulatory motif for optimal viral replication fitness.
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Authors
Gisela J. van der Velden, Monique A. Vink, Bep Klaver, Atze T. Das, Ben Berkhout,