Article ID Journal Published Year Pages File Type
6141057 Virology 2013 10 Pages PDF
Abstract
► The SIV mRNAs encoding Rev and Env protein have an upstream AUG codon. ► This upstream uAUG4 down-regulates Rev protein expression. ► By down-regulating Rev translation, uAUG4 up-regulates Env translation. ► uAUG4 “Kozak strength” and overlap with the Rev ORF ensure optimal Env translation. ► uORF4 is an important regulatory motif for optimal viral replication fitness.
Related Topics
Life Sciences Immunology and Microbiology Virology
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