Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6141104 | Virology | 2012 | 4 Pages |
Abstract
We used a luciferase-based assay to test the ability of 29 viral types, representing all current species within the Alphapapillomavirus genus, to activate the hTERT promoter. We show that oncogenic types specifically activate the hTERT promoter, while non-oncogenic types do not. Statistical analysis supports the notion that activation of the hTERT promoter is uniquely associated with oncogenic types, independent of evolutionary relationships. This finding begins to shed light on the viral phenotypes correlated with oncogenic potential.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Koenraad Van Doorslaer, Robert D. Burk,