| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6141178 | Virology | 2012 | 7 Pages |
Abstract
Hepatitis C virus infects almost 170 million people per year but its assembly pathway, architecture and the structures of its envelope proteins are poorly understood. Using electron tomography of plastic-embedded sections of insect cells, we have visualized the morphogenesis of recombinant Hepatitis C virus-like particles. Our data provide a three-dimensional sketch of viral assembly at the endoplasmic reticulum showing different budding stages and contiguity of buds. This latter phenomenon could play an important role during the assembly of wt-HCV and explain the size-heterogeneity of its particles.
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Authors
Daniel Badia-Martinez, Bibiana Peralta, German Andrés, Milagros Guerra, David Gil-Carton, Nicola G.A. Abrescia,