Bifunctional iridium-(2-aminoterephthalate)–Zr-MOF chemoselective catalyst for the synthesis of secondary amines by one-pot three-step cascade reaction

A simple and efficient method for the synthesis of N-alkyl amines via a cascade reaction (hydrogenation + reductive amination) using a new recyclable hybrid catalyst that combines the catalytic power of transition metal complexes with the architecture of metal organic frameworks (MOFs).

Graphical abstractA simple and efficient method for the synthesis of N-alkyl amines via a cascade reaction (hydrogenation + reductive amination) using a new recyclable hybrid catalyst that combines the catalytic power of transition metal complexes with the architecture of metal organic frameworks (MOFs).Figure optionsDownload full-size imageDownload high-quality image (192 K)Download as PowerPoint slideHighlights► Ir–Zr-MOFs as catalyst. ► Multistep reactions with MOF catalysts. ► One-pot reductive amination of carbonyl compounds with nitroarenes.