Article ID Journal Published Year Pages File Type
6141305 Virology 2012 12 Pages PDF
Abstract
► EV71 capsid region determining viral infectivity and mouse lethality. ► VP2149M and VP1145E showed greater viral infectivity and cytotoxicity. ► VP2149M and VP1145E synergistically enhanced viral binding and RNA accumulation. ► VP2149M and VP1145E markedly reduced value of 50% lethal dose in vivo.
Keywords
Related Topics
Life Sciences Immunology and Microbiology Virology
Preview
Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement
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