Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6141588 | Virology | 2010 | 9 Pages |
Abstract
The frequency of HBV mutations differed between the co-infected and mono-infected patients when comparing patients with the same genotype. BCP mutations A1762T and G1764A were significantly more frequent in HBV genotype C mono-infection and the -1G frameshift was significantly more frequent in co-infection and was only observed in HBV genotype A co-infection. PreS2 deletions were observed more frequently in the setting of co-infection. Further work is needed to determine if these mutational patterns influence the differences in liver disease progression in HIV-HBV co-infected and HBV mono-infected patients.
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Authors
Jennifer Audsley, Margaret Littlejohn, Lilly Yuen, Joe Sasadeusz, Anna Ayres, Christopher Desmond, Tim Spelman, George Lau, Gail V. Matthews, Anchalee Avihingsanon, Eric Seaberg, Frances Philp, Melissa Saulynas, Kiat Ruxrungtham, Gregory J. Dore,