Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6141778 | Virology | 2009 | 4 Pages |
Abstract
Intratypic diversity of human papillomavirus (HPV) genome is generally characterized by point mutation, insertion, and/or deletion. Using PCR-based cloning and sequencing, we detected concurrent infection with 8 HPV16 variants in a woman enrolled in the ASCUS-LSIL Triage Study. The European variant was the major variant; each of the 7 minor variants had partial DNA sequences identical to the European variant and another part identical to the African 2 variant. At a follow-up visit, only an HPV16 African 2 variant was detected. Results from the present study suggest presence of intratypic recombination of HPV genome in natural infection.
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Authors
Mingjun Jiang, Long Fu Xi, Zoe R. Edelstein, Denise A. Galloway, Gary J. Olsem, William Chun-Che Lin, Nancy B. Kiviat,