Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6142184 | Virus Research | 2015 | 12 Pages |
Abstract
Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases characterized by the aggregation and accumulation of the misfolded prion protein in the brain. Other proteins such as β-amyloid, tau or Serum Amyloid-A (SAA) seem to share with prions some aspects of their pathogenic mechanism; causing a variety of so called prion-like diseases in humans and/or animals such as Alzheimer's, Parkinson's, Huntington's, Type II diabetes mellitus or amyloidosis. The question remains whether these misfolding proteins have the ability to self-propagate and transmit in a similar manner to prions. In this review, we describe the prion and prion-like diseases affecting animals as well as the recent findings suggesting the prion-like transmissibility of certain non-prion proteins.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Patricia Aguilar-Calvo, Consolación GarcÃa, Juan Carlos Espinosa, Olivier Andreoletti, Juan MarÃa Torres,