Article ID Journal Published Year Pages File Type
6142193 Virus Research 2015 7 Pages PDF
Abstract
PK has also been used as a tool to probe the structure of PrPSc. Mass spectrometry and antibodies have been used to identify PK cleavage sites in PrPSc. These results have been used to identify the more accessible, flexible stretches connecting the β-strand components in PrPSc. These data, combined with physical constraints imposed by spectroscopic results, were used to propose a qualitative model for the structure of PrPSc. Assuming that PrPSc is a four rung β-solenoid, we have threaded the PrP sequence to satisfy the PK proteolysis data and other experimental constraints.
Related Topics
Life Sciences Immunology and Microbiology Virology
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