Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6142457 | Virus Research | 2014 | 17 Pages |
Abstract
Influenza is a major burden to public health. Due to high mutation rates and selection pressure, mutant viruses emerge which are resistant to currently used antiviral drugs. Therefore, there is a need for the development of novel classes of antiviral drugs that suffer less from the emergence of resistant viruses. Antiviral drugs based on collectin-like surfactant protein D (SP-D) may fulfil these requirements. Especially porcine SP-D displays strong antiviral activity to influenza A viruses. In the present study the antiviral activity of recombinant porcine SP-D was investigated in ex vivo cultures of respiratory tract tissue infected with human influenza A virus of the H3N2 subtype. Porcine SP-D has antiviral activity in these test systems. It is suggested that porcine SP-D may be used as a venue to develop a novel class of antiviral drugs.
Keywords
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Virology
Authors
Marine L.B. Hillaire, Martin van Eijk, Stella E. Vogelzang-van Trierum, Ron A.M. Fouchier, Albert D.M. E. Osterhaus, Henk P. Haagsman, Guus F. Rimmelzwaan,