Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6142649 | Virus Research | 2014 | 4 Pages |
Abstract
Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Bruno Douradinha, Sean P. McBurney, Klecia M. Soares de Melo, Amanda P. Smith, Neel K. Krishna, Simon M. Barratt-Boyes, Jared D. Evans, Eduardo J.M. Nascimento, Ernesto T.A. Jr.,