| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6142816 | Virus Research | 2012 | 9 Pages |
Abstract
⺠EV30 can infect and replicate in human choroid plexus papilloma cells (HIBCPP). ⺠CXCL1, CXCL2 and CXCL3 are significantly up-regulated in HIBCPP following enteroviral infection. ⺠CXCL12 leads to a significant T lymphocyte migration across HIBCPP, whereas enteroviral stimulation has only a minor effect. ⺠This is the first human in vitro model of the BCSFB that enables studies of viral infection and CNS inflammation.
Keywords
RKIMDMPMNTEERBCSFBHBMECHTLVTBERIPAECLCBADAFCXCL3LPSCoxsackie adenovirus receptormonocyte derived macrophagesCPECVB3MOIq-PCRcytometric bead arrayTick borne encephalitisCytopathic effectSDS-PAGEsodium dodecyl sulphate polyacrylamide gel electrophoresisstandard deviationinterleukinCNSBlood–brain barrierBBBHuman brain microvascular endothelial cellscentral nervous systemlipopolysaccharideCARBlood–cerebrospinal fluid barrierCSFCerebrospinal fluidtransepithelial electrical resistanceMultiple sclerosispolymerase chain reactionquantitative real time polymerase chain reactionPCRhuman immunodeficiency virusHIVmultiplicity of infectionPolymorphonuclear granulocytes
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Henriette Schneider, Claudia Ellen Weber, Julia Schoeller, Ulrike Steinmann, Julia Borkowski, Hiroshi Ishikawa, Peter Findeisen, Ortwin Adams, Ruediger Doerries, Christian Schwerk, Horst Schroten, Tobias Tenenbaum,