Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6142848 | Virus Research | 2013 | 4 Pages |
Abstract
The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells following antigen stimulation in vitro tended to have a more prolonged period of high fevers and a longer duration of illness. Thus, an increase of EV71 epitope-specific Th2 type response may portend the poor prognosis for some HFMD patients.
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Authors
Ruicheng Wei, Lijuan Xu, Na Zhang, Kai Zhu, Juhao Yang, Chunhui Yang, Chaoyang Deng, Zhaomin Zhu, Anne S. De Groot, Ralf Altmeyer, Mei Zeng, Qibin Leng,