Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6142898 | Virus Research | 2013 | 10 Pages |
Abstract
⺠We are reporting constructions of genetically the modified rVSVNJ vector carrying HCV NS protein genes. ⺠The recombinant VSVNJ-M vector with the HCV NS genes expresses high levels of all different forms of the NS proteins. ⺠The recombinant VSVNJ-M vector can accommodate as much as 6000 bases of the foreign gene. ⺠The rVSVNJ M mutant virus infection induced a higher level of the IFN-β compared to the wild type virus. ⺠We confirmed that NS3 and NS4A proteins expressed from the rVSVNJ-M vector cleave HCV NS polyproteins.
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Authors
Hwa-Yong An, Gyoung Nyoun Kim, Kunyu Wu, C. Yong Kang,