Cellular RNA helicases and HIV-1: Insights from genome-wide, proteomic, and molecular studies

RNA helicases are ubiquitous in plants and animals and function in many cellular processes. Retroviruses, such as human immunodeficiency virus (HIV-1), encode no RNA helicases in their genomes and utilize host cellular RNA helicases at various stages of their life cycle. Here, we briefly summarize the roles RNA helicases play in HIV-1 replication that have been identified recently, in part, through genome-wide screenings, proteomics, and molecular studies. Some of these helicases augment virus propagation while others apparently participate in antiviral defenses against viral replication.

► We review RNA helicases that affect HIV-1 replication. ► Potential drugs against RNA helicase for HIV-1 therapy are discussed. ► RNA helicases are used in diverse cellular functions.