Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6142945 | Virus Research | 2013 | 15 Pages |
Abstract
Our work over the past eight years has focused on the use of HIV-1 lentiviral vectors (lentivectors) for the genetic modification of dendritic cells (DCs) to control their functions in immune modulation. DCs are key professional antigen presenting cells which regulate the activity of most effector immune cells, including T, B and NK cells. Their genetic modification provides the means for the development of targeted therapies towards cancer and autoimmune disease. We have been modulating with lentivectors the activity of intracellular signalling pathways and co-stimulation during antigen presentation to T cells, to fine-tune the type and strength of the immune response. In the course of our research, we have found unexpected results such as the surprising immunosuppressive role of anti-viral signalling pathways, and the close link between negative co-stimulation in the immunological synapse and T cell receptor trafficking. Here we review our major findings and put them into context with other published work.
Keywords
MLVpeptide–MHC complextumour associated antigenX-SCIDCentral DNA flapcPPTWPRERREpMHCCostimulationT helperMDSCnucleocapsidIRFTregTLRNF-κBOVAERKTAAJnkPD-1PD-L1TCrc-Jun KinaseMAPKOvalbuminToll-like receptorCancerRegulatory T cellDendritic cellmyeloid-derived suppressor cellinterferon regulatory factorRev response elementnuclear factor kappa-light-chain-enhancer of activated B cellsMatrixmitogen activated protein kinaseX-linked severe combined immunodeficiencyCapsidextracellular signal-regulated kinaseT cell receptor
Related Topics
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Virology
Authors
Therese Liechtenstein, Noemi Perez-Janices, Christopher Bricogne, Alessio Lanna, Inès Dufait, Cleo Goyvaerts, Roberta Laranga, Antonella Padella, Frederick Arce, Mehdi Baratchian, Natalia Ramirez, Natalia Lopez, Grazyna Kochan, Idoia Blanco-Luquin,