Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6143066 | Virus Research | 2012 | 7 Pages |
Abstract
⺠In vivo electroporation markedly enhanced delivery of M2e-HSP70c fusion gene and induced high level of influenza M2e specific antibodies. ⺠Evaluation of serological results determined that HSP70359-610 (HSP70c) fused to M2e drastically enhanced the immunogenicity of influenza M2e protein. ⺠M2e-HSP70c based DNA vaccine combined with in vivo electroporation was able to confer both protection against lethal challenge of H1N1 virus and reduce viral load in lung homogenates of the inoculated mice.
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Authors
Mohammad Hossein Zabeh Jazi, Mehran Dabaghian, Majid Tebianian, Mohammad Javad Gharagozlou, Seyyed Mahmoud Ebrahimi,