Article ID Journal Published Year Pages File Type
6143069 Virus Research 2012 12 Pages PDF
Abstract
► MHV nsp15 is distributed throughout the cytoplasm of virus-infected cells. ► MHV but not SARS-CoV or TGEV nsp15 formed speckles when ectopically expressed in cell. ► Two domains (I and III) within nsp15 are responsible for the speckle formation. ► A novel protein-interaction domain is identified in the C-terminus of MHV nsp15. ► nsp15s from the 3 coronaviruses have differential effects on MHV replication.
Related Topics
Life Sciences Immunology and Microbiology Virology
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