Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6143069 | Virus Research | 2012 | 12 Pages |
Abstract
⺠MHV nsp15 is distributed throughout the cytoplasm of virus-infected cells. ⺠MHV but not SARS-CoV or TGEV nsp15 formed speckles when ectopically expressed in cell. ⺠Two domains (I and III) within nsp15 are responsible for the speckle formation. ⺠A novel protein-interaction domain is identified in the C-terminus of MHV nsp15. ⺠nsp15s from the 3 coronaviruses have differential effects on MHV replication.
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Authors
Jianzhong Cao, Xuming Zhang,