| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6143105 | Virus Research | 2012 | 7 Pages |
Abstract
⺠We observed in vitro HSV-2 proliferation increased cellular p21 expression, p53 Ser20 phosphorylation. ⺠Knockdown of endogenous p21 by specific siRNAs severely impaired HSV2 propagation. ⺠Cells lacking endogenous p53 mechanism were defective in p21 up-regulation and HSV-2 production. ⺠We conclude that the p53-p21 pathway is required for efficient lytic replication of HSV-2.
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Authors
Qi Zhou, Meng Zhu, Hao Zhang, Ting Yi, John D. Klena, Yihong Peng,