| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6143164 | Virus Research | 2012 | 4 Pages |
Abstract
⺠Because of codon bias, the expression level of native VP2 is very low in Sf9 cells. To overcome the obstacles, we converted wild-type VP2 codons into codons that are more common in insect genes. ⺠Our results showed that this change greatly increased VP2 protein production in Sf9 cells and optVP2 yielded stable and high-quality VLPs. ⺠The results of animal experiment also indicate that these VLPs retained good immunogenicity and had strong immunogenicity in susceptible geese.
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Authors
Zongyan Chen, Chuanfeng Li, Yingqi Zhu, Binbin Wang, Chunchun Meng, Guangqing Liu,