| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6143180 | Virus Research | 2012 | 11 Pages |
Abstract
⺠We analyzed genetic signatures in V3/gp41 underlying HIV-1 clade C co-receptor usage. ⺠Specific V3 signatures significantly associated with CCR5 or CXCR4 usage were found. ⺠Specific gp41 mutations significantly associated with R5 or X4 usage were found. ⺠Statistically significant correlations between V3-gp41 tropic signatures were found. ⺠Our findings fortify prior remarks that tropic-determinants may also reside in gp41.
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Authors
Salvatore Dimonte, Muhammed Babakir-Mina, Fabio Mercurio, Domenico Di Pinto, Francesca Ceccherini-Silberstein, Valentina Svicher, Carlo-Federico Perno,