Article ID Journal Published Year Pages File Type
6143190 Virus Research 2012 6 Pages PDF
Abstract
► CHO cell-adapted strains of HEV71 sub-genogroups B5 and C2 were isolated. ► HEV71 sub-genogroup C4 failed to adapt to CHO cells during serial passage. ► CHO cell-adapted HEV71 has amino acid mutation at position 149 of the VP2 gene. ► HEV71-C4 constructed to contain mutation VP2-K149 → I or M can grow in CHO cells.
Related Topics
Life Sciences Immunology and Microbiology Virology
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