| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6143214 | Virus Research | 2012 | 8 Pages |
Abstract
⺠We investigated RNA interference (RNAi) as antiviral agent against rabies using two small interfering RNAs (siRNAs) targeting rabies virus (RV) nucleoprotein (N) and polymerase (L) genes. ⺠The antiviral potential of siRNAs delivered using adenoviruses in BHK-21 cells showed marked inhibition in RV multiplication, RV titer knockdown of RV gene transcripts. ⺠Mice treated with adenoviruses expressing siRNAs showed 66.6% and 33.3% protection with adenoviruses expressing siRNAs against RV-N and RV-L genes, respectively against lethal rabies virus challenge.
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Authors
Praveen K. Gupta, Arvind A. Sonwane, Niraj K. Singh, Chetan D. Meshram, Shyam S. Dahiya, Sachin S. Pawar, Swatantra P. Gupta, V.K. Chaturvedi, Mohini Saini,