| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6143284 | Virus Research | 2012 | 7 Pages |
Abstract
⺠We describe the establishment of a new animal model of human hantavirus infection. ⺠Hantaan virus strain AA57 causes a lethal pulmonary disease in 2-week-old ICR mice. ⺠A large volume of pleural effusion was collected from the dead AA57-infected mice. ⺠The highest virus and pathologic changes were observed in the lungs of sick mice. ⺠The symptoms of this mouse model are similar to those of human hantavirus infection.
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Immunology and Microbiology
Virology
Authors
Takahiro Seto, Noriyo Nagata, Keisuke Yoshikawa, Osamu Ichii, Takahiro Sanada, Ngonda Saasa, Yuka Ozaki, Yasunori Kon, Kentaro Yoshii, Ikuo Takashima, Hiroaki Kariwa,