Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6143284 | Virus Research | 2012 | 7 Pages |
Abstract
⺠We describe the establishment of a new animal model of human hantavirus infection. ⺠Hantaan virus strain AA57 causes a lethal pulmonary disease in 2-week-old ICR mice. ⺠A large volume of pleural effusion was collected from the dead AA57-infected mice. ⺠The highest virus and pathologic changes were observed in the lungs of sick mice. ⺠The symptoms of this mouse model are similar to those of human hantavirus infection.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Takahiro Seto, Noriyo Nagata, Keisuke Yoshikawa, Osamu Ichii, Takahiro Sanada, Ngonda Saasa, Yuka Ozaki, Yasunori Kon, Kentaro Yoshii, Ikuo Takashima, Hiroaki Kariwa,