| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6143338 | Virus Research | 2011 | 14 Pages |
Abstract
⺠Recombination-dependent DNA replication (RDR) plays an essential role in the replication cycle of many dsDNA viruses. ⺠Many recombination proteins are present and conserved in dsDNA viruses. ⺠RDR provides the means to generate linear concatemeric viral DNA. ⺠The molecular mechanisms of RDR depend on the nature (circular or linear) of the dsDNA molecule. ⺠RDR is involved in spread of antibiotic resistance and transfer of pathogenicity islands.
Keywords
dsDNAPACSSASaPIMRNHSV-1Mre11–Rad50–Nbs1 complexssDNARDRSSBDSBSingle-stranded DNAdouble-stranded DNAOB-foldORIHolliday junctionSingle-strand annealingPAITerminal repeatbreak-induced replicationPathogenicity islanddouble strand breakorigin of replicationSingle-stranded DNA binding proteinReplication fork reversal
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Authors
Ambra Lo Piano, MarÃa I. MartÃnez-Jiménez, Lisa Zecchi, Silvia Ayora,