Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6143346 | Virus Research | 2011 | 8 Pages |
Abstract
⺠HCV core protein play a role in HCC at least in part by altering the methylation status of CDH1 promoter. ⺠Overexpression of the HCV genotype 1b core protein in HuH7 cells leads to a decrease of the CDH1. ⺠Promoter methylation is associated with overexpression of SIRT1. ⺠Treatment with SIRT1 inhibitor (sirtinol) was able to reduce the CDH1 promoter hypermethylation. ⺠The employment of small molecules (such as SIRT1 inhibitors) as anticancer agents in combination with other therapeutic strategies is discussed.
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Authors
Maria Ripoli, Raffaela Barbano, Teresa Balsamo, Claudia Piccoli, Virgilio Brunetti, Michelina Coco, Gianluigi Mazzoccoli, Manlio Vinciguerra, Valerio Pazienza,