Article ID Journal Published Year Pages File Type
6143348 Virus Research 2011 9 Pages PDF
Abstract
► We establish HCV-Tg mice regulated by the Cre/loxP system and an AdV/Cre. ► We examine effects of an AdV/Cre bearing the EF1α promoter, AxEFCre. ► AxEFCre-injected HCV-Tg mice show clearly liver injury due to HCV protein expression. ► AxEFCre injection enables the HCV-Tg mice to persistently express HCV protein. ► AxEFCre efficiently promotes DNA recombination in vivo without a severe hepatitis.
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Life Sciences Immunology and Microbiology Virology
Preview
Conditional gene expression in hepatitis C virus transgenic mice without induction of severe liver injury using a non-inflammatory Cre-expressing adenovirus
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