| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6143399 | Virus Research | 2011 | 11 Pages |
Abstract
⺠We developed an efficient pseudotype virus system for HCoV-NL63. ⺠We identified the domains and critical residues involved in the NL63 S-mediated viral entry. ⺠This viral system is useful for investigation of the effect of NL63 S on ACE2 expression and shedding as well as the pathogenicity. ⺠Our study may advance our understanding of the molecular mechanism of NL63 S-ACE2 interaction. ⺠Our data may provide important information for the development of vaccines, small peptides, compounds, or neutralizing antibodies against NL63 infections.
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Authors
Han-Xin Lin, Yan Feng, Xinming Tu, Xuesen Zhao, Chih-Heng Hsieh, Lauren Griffin, Murray Junop, Chengsheng Zhang,