Comparison of innate immune responses to pathogenic and putative non-pathogenic hantaviruses in vitro

► Pathogenic hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. However, not all hantaviruses are human pathogens. ► We have examined the pathogenesis of different hantavirus groups by comparing the innate immune responses induced in the host cell following infection by pathogenic (Sin Nombre, Hantaan, and Seoul virus) and putative non-pathogenic (Prospect Hill, Tula, and Thottapalayam virus) hantaviruses. ► The degree of innate immune inhibition may play an important role to distinguish pathogenic and non-pathogenic hantaviruses.