Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6143850 | American Journal of Obstetrics and Gynecology | 2015 | 19 Pages |
Abstract
Uterine overdistention by inflation of an intraamniotic balloon is associated with an inflammatory pulse that precedes and correlates with preterm labor. Our results indicate that inflammation is an early event after a mechanical stress on the uterus and leads to preterm labor when the stress is sufficiently great. Further, we find evidence of uterine tissue remodeling and muscle growth as a common, perhaps compensatory, response to uterine distension.
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Authors
Kristina M. MD, Natasha MBBS, MRCOG, BSCCP, Aarthi R. MD, PhD, Roger C. MD, PhD, Lisa BS, Ananya MSc, Jesse BS, Aasthaa PhD, Louis BS, Bronwen R. BSc, PhD, Suren R. PhD, G. Michael MSc, Cliff MS, Keith DVM, Audrey E. DVM, Theodor K. PhD, James MSc,