| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6145856 | American Journal of Obstetrics and Gynecology | 2013 | 6 Pages |
Abstract
Circulating progesterone is significantly lower in PE women compared to controls. 17-OHPC attenuates hypertension in response to placental ischemia in RUPP rats. Progesterone blunts vascular ET-1 stimulated at cellular level by sera from PE women or RUPP rats. Decreased circulating progesterone is associated with stimulation of ET-1. 17-OHPC supplementation blunts hypertension and progesterone blunts endothelial cell ET-1 secretion in response to placental ischemia.
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Authors
Luissa V. DO, Kedra PhD, Janae BS, James MD, Babbette PhD,