Novel single nucleotide polymorphisms in the superoxide dismutase 1 and 2 genes among children with myelomeningocele

We identified 1 novel variant and made the second report of an additional variant in the SOD genes studied. The variant located in the 3′-UTR of SOD1 is predicted to alter microribonucleic acid (miRNA) binding. The variant located in the 3′-UTR of SOD2 is predicted to alter 2 miRNA binding sites and potentially affects messenger ribonucleic acid production. We also identified 2 known single-nucleotide polymorphisms that occur in significantly different frequency compared with the unaffected population controls.