Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6149209 | Archives of Medical Research | 2011 | 4 Pages |
Abstract
The results of this study suggest that V-allele genotypes in the H3 receptor gene are related to migraine risk in the Mexican population. We propose the hypothesis that the V-allele genotypes in the H3 receptor gene increase the population of inactive receptors, enhancing the inhibition of the negative feedback mechanism on the H3 receptor and increasing histamine release, which correlates with migraine attacks in susceptible patients. The case-control study reinforces the role of histamine in migraine pathogenesis.
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Authors
Rebeca O. Millán-Guerrero, Luz M. Baltazar-RodrÃguez, Martha I. Cárdenas-Rojas, Mario RamÃrez-Flores, Sara Isais-Millán, Ivan Delgado-Enciso, Ramiro Caballero-Hoyos, BenjamÃn Trujillo-Hernández,