Size Doesn't Matter: Cortical Stroke Lesion Volume Is Not Associated With Upper Extremity Motor Impairment and Function in Mild, Chronic Hemiparesis

Data suggest no relationship between lesion volume and UE impairment, and a small, clinically insignificant relationship between lesion volume and UE motor function. Stroke causes metabolic changes in intact regions and diffuse structural loss in anatomically remote regions from the infarction. These other factors may account for variance in motor outcomes after stroke.