Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6155806 | Translational Research | 2016 | 120 Pages |
Abstract
A large and growing portion of the human population, especially in developed countries, suffers 1 or more chronic, often quite burdensome ailments which either are overtly inflammatory in nature or are suspected to be of inflammatory origin, but for which investigations to date have failed to identify specific causes, let alone unifying mechanisms underlying the multiple such ailments that often afflict such patients. Relatively recently described as a non-neoplastic cousin of the rare hematologic disease mastocytosis, mast cell (MC) activation syndrome-suspected to be of greatly heterogeneous, complex acquired clonality in many cases-is a potential underlying/unifying explanation for a diverse assortment of inflammatory ailments. A brief review of MC biology and how aberrant primary MC activation might lead to such a vast range of illness is presented.
Keywords
TregPRCAPolycythemia veraSCAMDSIBDIBSGWIDM2MCsTSHDM1MCADNICMCGRPMCASBMSRLSTRPV1PCOSGERDTNFT-regulatory cellNERDCCSSM-AHNMDCIDEDSCFSCRHPOTSBPADNon-Ischemic CardiomyopathyH&EHuman leukocyte antigenHLABipolar affective disorderAutism spectrum disorderSystemic mastocytosiselectrocardiographicECGimmunoglobulin interferonIFNinterleukinChronic inflammatory diseaseGulf War Illnessnon-erosive reflux diseasegastroesophageal reflux diseaseMast cell activation diseasechronic kidney diseaseInflammatory bowel diseaseMultiple chemical sensitivityCNSGastrointestinalDiabetes mellitus type 1Diabetes mellitus type 2Ehlers-Danlos syndromePostural orthostatic tachycardia syndromepolycystic ovarian syndromeChronic fatigue syndromeBurning mouth syndromeMast cell activation syndromeRestless leg syndromemyelodysplastic syndromeirritable bowel syndromecentral nervous systemMISTtumor necrosis factorFibromyalgiaMast cellCSFCerebrospinal fluidCKDASDHematoxylin and Eosincorticotropin releasing hormonethyroid stimulating hormonepolymerase chain reactionPCREssential hypertensioncalcitonin gene-related peptideaciSickle cell anemia
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Authors
Lawrence B. Afrin,