Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6155913 | Translational Research | 2015 | 11 Pages |
Abstract
Immunoglobulin A nephropathy (IgAN) is characterized by a qualitative abnormality of IgA in the circulation and IgA deposition in the renal mesangium. Recent research has indicated that pathogenic IgA may originate from affected tonsils. Follicular dendritic cell-secreted protein (FDC-SP), a small novel secretory protein that may regulate the induction of B-cell responses, has been suggested to control IgA production. Given this background, this study investigated the expression of FDC-SP and its correlation with IgA production in the tonsils of IgAN patients. Immunohistochemistry and reverse transcription-polymerase chain reaction were used to compare the expression of FDC-SP in the tonsils of IgAN patients with tonsillitis and of non-IgAN patients with chronic tonsillitis. The location of FDC-SP in tonsillar tissue was confirmed by double immunofluorescence. We found that FDC-SP expression significantly decreased and was correlated negatively with enhanced IgA production in the tonsils of IgAN patients. FDC-SP secreted by follicular dendritic cells may act on germinal center B cells and participate in the modulation of IgA generation in the tonsils. Our study demonstrated that FDC-SP may be involved in IgA production in the tonsils of IgAN patients, making this protein an attractive candidate immunomodulator, and highlighting a promising strategy for therapeutic intervention in IgAN.
Keywords
Related Topics
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Medicine and Dentistry
Medicine and Dentistry (General)
Authors
Hong-Xue Meng, Hui-Ning Li, Jia-Shi Geng, Rintaro Ohe, Xiao-Yu Yu, Xiao-Qiang E, Fei Ye, Su-Ran Yang, Tomoya Kato, Lei Zhang, Akihiro Ishida, Nobuo Ohta, Xiao-Ming Jin, Seiji Kakehata, Jing-Shu Geng, Mitsunori Yamakawa,