| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6156120 | Translational Research | 2015 | 8 Pages |
Abstract
Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N6-methyl-adenosine (m6A) modification is the most abundant and can be removed by specific mammalian enzymes. m6A modification is recognized by families of RNAÂ binding proteins that affect many aspects of mRNA function. mRNA/lncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylation and histone modification.
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Authors
Nian Liu, Tao Pan,