Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6156155 | Translational Research | 2013 | 11 Pages |
Abstract
Approximately 40% of patients with Henoch-Schonlein purpura (HSP) develop Henoch-Schonlein purpura nephritis (HSPN) after 4 to 6 weeks of subcutaneous hemorrhaging. Immunoglobulin-A nephropathy (IgAN) and HSPN have numerous similarities, which can cause difficulty in correctly diagnosing the disorder during a differential diagnosis. The pathogenesis of the 2 diseases is not clear. We enrolled 137 patients with HSPN, 107 patients with IgAN, and 28 healthy (control) patients in our study. The levels of alpha-smooth muscle actin (α-SMA), c-Met, and Gal-deficient IgA1 (Gd-IgA1) in the 3 patient groups were determined and compared. The α-SMA, c-Met, and Gd-IgA1 levels and the clinical data from the patients with HSPN were analyzed for any correlations. The α-SMA and c-Met levels of the HSPN group were significantly higher than those of the IgAN and healthy control groups (P < 0.01). The Gd-IgA1 levels of the HSPN and IgAN groups were significantly different from the Gd-IgA1 level of the healthy control group (P < 0.01). The α-SMA levels of the HSPN group were positively correlated with blood urea nitrogen levels, serum creatinine levels, hematuria index, and proteinuria levels (P < 0.01). The c-Met levels of the HSPN group were positively correlated with the blood urea nitrogen and serum creatinine levels (P < 0.01). There were no significant differences among the α-SMA, c-Met, and Gd-IgA1 levels or the clinical data for the child and adult patients with HSPN. The serum levels of α-SMA and c-Met in patients with HSPN may be associated with the degree of disease severity. Gd-IgA1 is involved in the common immunologic pathogenesis of HSPN and IgAN.
Keywords
α-SMAphosphate-buffered saline containing 0.05% Tween 20vvlSambucus nigra agglutininHGFPNASNAhpfPBS-THspIgANAlpha-smooth muscle actinpeanut agglutininImmunoglobulin A nephropathyimmunoglobulin Enzyme-linked immunosorbent assayELISABUNHepatocyte growth factorhigh-power fieldblood urea nitrogenHenoch-Schönlein purpuraserum creatinineGalGalactoseSCR
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Authors
Lei Zhang, Changsong Han, Chuanhui Sun, Hongxue Meng, Fei Ye, Shiping Na, Fulai Chen, Duo Zhang, Xiaoming Jin,