Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6157489 | American Journal of Kidney Diseases | 2015 | 7 Pages |
Abstract
A spate of recent publications describes a newly recognized form of glomerulonephritis associated with active staphylococcal infection. The key kidney biopsy findings, glomerular immunoglobulin A (IgA) deposits dominant or codominant with IgG deposits, resemble those of IgA nephritis. Many authors describe this condition as “postinfectious” and have termed it “poststaphylococcal glomerulonephritis.” However, viewed through the prism of poststreptococcal glomerulonephritis, the prefix “post” in poststaphylococcal glomerulonephritis is historically incorrect, illogical, and misleading with regard to choosing therapy. There are numerous reports describing the use of high-dose steroids to treat poststaphylococcal glomerulonephritis. The decision to use steroid therapy suggests that the treating physician believed that the dominant problem was a postinfectious glomerulonephritis, not the infection itself. Unfortunately, steroid therapy in staphylococcus-related glomerulonephritis can precipitate severe staphylococcal sepsis and even death and provides no observable benefits. Poststreptococcal glomerulonephritis is an authentic postinfectious glomerulonephritis; poststaphylococcal glomerulonephritis is not. Making this distinction is important from the perspective of history, pathogenesis, and clinical management.
Keywords
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Authors
Richard J. MD, Anthony MD, Jason MD, Courtney MD, Samir MD, Anjali MD, Tibor MD, John MD, Brad MD, Lee A. MD,