Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6159773 | The Journal of Urology | 2009 | 7 Pages |
Abstract
Compared to controls, female patients with interstitial cystitis/painful bladder syndrome showed increased activation of a defensive emotional circuit in the context of a threat of abdominal pain. This pattern is similar to that previously reported in patients with anxiety disorders as well as those with irritable bowel syndrome. Since these circuits have an important role in central pain amplification related to affective and cognitive processes, these results support the hypothesis that the observed abnormality may be involved in the enhanced perception of bladder signals associated with interstitial cystitis/painful bladder syndrome.
Keywords
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Authors
Christian Twiss, Lisa Kilpatrick, Michelle Craske, C.A. Tony Buffington, Edward Ornitz, Larissa V. RodrÃguez, Emeran A. Mayer, Bruce D. Naliboff,