Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6160840 | Kidney International | 2014 | 10 Pages |
Abstract
In this prospective study, we measured serum levels of the soluble urokinase receptor (suPAR) in pediatric patients with nephrotic syndrome of various etiologies. Mean levels of suPAR were 3316Â pg/ml in 99 patients with steroid-resistant focal segmental glomerulosclerosis and 3253Â pg/ml in 117 patients with biopsy-proven minimal change disease, which were similar to that of 138 patients with steroid-sensitive nephrotic syndrome (3150Â pg/ml) and 83 healthy controls (3021Â pg/ml). Similar proportions of patients in each group had suPAR over 3000Â pg/ml. Compared with controls, suPAR levels were significantly higher in patients with focal segmental glomerulosclerosis (FSGS) and estimated glomerular filtration rate (eGFR) under 30Â ml/min per 1.73Â m2 (6365Â pg/ml), congenital nephrotic syndrome (4398Â pg/ml), and other proteinuric diseases with or without eGFR under 30Â ml/min per 1.73Â m2 (5052 and 3875Â pg/ml, respectively; both significant). There were no changes following therapy and during remission. Levels of suPAR significantly correlated in an inverse manner with eGFR (r=-0.36) and directly with C-reactive protein (r=0.20). The urinary suPAR-to-creatinine ratio significantly correlated with proteinuria (r=0.25) in 151 patients and controls. Using generalized estimating equations approach, serum suPAR significantly correlated with eGFR (coefficient=-13.75), age at sampling (2.72), and C-reactive protein (39.85). Thus, serum suPAR levels in nephrotic syndrome are similar to controls, and do not discriminate between FSGS, minimal change disease, or steroid-responsive illness.
Keywords
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Nephrology
Authors
Aditi Sinha, Jaya Bajpai, Savita Saini, Divya Bhatia, Aarti Gupta, Mamta Puraswani, Amit K. Dinda, Sanjay K. Agarwal, Shailaja Sopory, Ravindra M. Pandey, Pankaj Hari, Arvind Bagga,