Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6161792 | Kidney International | 2015 | 8 Pages |
Abstract
There are few reports of associations between alcohol consumption and risk of chronic kidney disease (CKD). To investigate this further, we studied 5476 participants aged 28-75 years in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population-based cohort, who were free of CKD at baseline (1997/1998). Alcohol consumption was self-reported on a questionnaire validated against serum high-density lipoprotein cholesterol. The primary outcome was de novo CKD defined as a combination of a creatinine-cystatin C-based estimated glomerular filtration rate (eGFR) under 60âml/min per 1.73âm2 and/or the mean of two consecutive 24-h urinary albumin excretions over 30âmg. During four serial follow-up examinations (median 10.2 years until February 2012), 903 participants developed CKD. Compared with those abstaining from alcohol, the multivariable-adjusted hazard ratios (95% confidence interval) for CKD risk were 0.85 (0.69-1.04) for occasional (under 10âg/week), 0.82 (0.69-0.98) for light (10-69.9âg/week), 0.71 (0.58-0.88) for moderate (70-210âg/week), and 0.60 (0.42-0.86) for heavier (over 210âg/week) alcohol consumers (significant trend). Similar inverse associations for alcohol consumption were found when CKD was defined as eGFR <60âml/min per 1.73âm2 or as 24-h urinary albumin excretion over 30âmg. Thus, in this population-based cohort, alcohol consumption was inversely associated with the risk of developing CKD.
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Authors
Sarah H. Koning, Ron T. Gansevoort, Kenneth J. Mukamal, Eric B. Rimm, Stephan J.L. Bakker, Michel M. Joosten,