Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6162183 | Kidney International | 2013 | 8 Pages |
Abstract
Dietary phosphorus consumption has risen steadily in the United States. Oral phosphorus loading alters key regulatory hormones and impairs vascular endothelial function, which may lead to an increase in left ventricular mass (LVM). We investigated the association of dietary phosphorus with LVM in 4494 participants from the Multi-Ethnic Study of Atherosclerosis, a community-based study of individuals who were free of known cardiovascular disease. The intake of dietary phosphorus was estimated using a 120-item food frequency questionnaire and the LVM was measured using magnetic resonance imaging. Regression models were used to determine associations of estimated dietary phosphorus with LVM and left ventricular hypertrophy (LVH). Mean estimated dietary phosphorus intake was 1167Â mg/day in men and 1017Â mg/day in women. After adjustment for demographics, dietary sodium, total calories, lifestyle factors, comorbidities, and established LVH risk factors, each quintile increase in the estimated dietary phosphate intake was associated with an estimated 1.1Â g greater LVM. The highest gender-specific dietary phosphorus quintile was associated with an estimated 6.1Â g greater LVM compared with the lowest quintile. Higher dietary phosphorus intake was associated with greater odds of LVH among women, but not men. These associations require confirmation in other studies.
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Authors
Kalani T. Yamamoto, Cassianne Robinson-Cohen, Marcia C. de Oliveira, Alina Kostina, Jennifer A. Nettleton, Joachim H. Ix, Ha Nguyen, John Eng, Joao A.C Lima, David S. Siscovick, Noel S. Weiss, Bryan Kestenbaum,