Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6162467 | Kidney International | 2011 | 7 Pages |
Abstract
To examine whether a higher body mass index (BMI) in kidney recipients is associated with delayed graft function (DGF), we analyzed data from 11,836 hemodialysis patients in the Scientific Registry of Transplant Recipients who underwent kidney transplantation. The patient cohort included women, blacks, and diabetics; the average age was 49 years; and the mean BMI was 26.8Â kg/m2. After adjusting for relevant covariates, multivariate logistic regression analyses found that one standard deviation increase in pretransplant BMI was associated with a higher risk of DGF (odds ratio (OR) 1.35). Compared with patients with a pretransplant BMI of 22-24.99Â kg/m2, overweight patients (BMI 25-29.99Â kg/m2), mild obesity patients (BMI 30-34.99Â kg/m2), and moderate-to-severe obesity patients (BMI 35Â kg/m2 and over) had a significantly higher risk of DGF, with ORs of 1.30, 1.42, and 2.18, respectively. Similar associations were found in all subgroups of patients. Hence, pretransplant overweight or obesity is associated with an incrementally higher risk of DGF.
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Authors
Miklos Z. Molnar, Csaba P. Kovesdy, Istvan Mucsi, Suphamai Bunnapradist, Elani Streja, Mahesh Krishnan, Kamyar Kalantar-Zadeh,