Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6169922 | The Breast | 2015 | 7 Pages |
Abstract
Young patients with breast cancer (BC) are often concerned about treatment-induced infertility and express maternity desire. Conception after BC does not seem to affect outcome, but information in estrogen-receptor positive (ER+) disease is not definitive. From September 2012-March 2013, 212 evaluable patients with ER+ early BC, <37 years at diagnosis, from 5 regions (Europe/US/Canada/Middle-East/Australia) answered a survey about fertility concerns, maternity desire and interest in a study of endocrine therapy (ET) interruption to allow pregnancy. Overall, 37% of respondents were interested in the study; younger patients (â¤30 years) reported higher interest (57%). Motivation in younger patients treated >30 months was higher (83%) than in older women (14%), interest was independent of age in patients treated for â¤30 months. A prospective study in this patient population seems relevant and feasible. The International-Breast-Cancer-Study-Group (IBCSG), within the Breast-International-Group (BIG) - North-American-Breast-Cancer-Groups (NABCG) collaboration, is launching a study (POSITIVE) addressing ET interruption to allow pregnancy.
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Authors
Olivia Pagani, Monica Ruggeri, Silvia Manunta, Christobel Saunders, Fedro Peccatori, Fatima Cardoso, Bella Kaufman, Shani Paluch-Shimon, Hanan Gewefel, Elisa Gallerani, OMalkahi Abulkhair, Barbara Pistilli, Ellen Warner, Emmanouil Saloustros,